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CURRENT AND FUTURE TESTING SITES AND COLLABORATORS
Harvard University’s Longwood campus has the densest concentration of hospitals in the world. At the Massachusetts General Hospital, in the department of Anesthesia and Critical Care, Dr. James Williams collects EEGs from rats and humans subjected to varying amounts and types of anesthetics. At the Brigham & Women’s Hospital, Dr. Charles Czeisler, the leader of NASA’s National Space Biomedical Research Institute’s Human Performance Factors, Sleep and Chronobiology Team analyzes brain patterns from sleeping astronauts in orbit. Dr. Czeisler presided over STS-95, the mission which brought John Glenn back to space. Drs. Williams and Czeisler think that the single channel capability of the methods developed by NeuroVigil, Inc., are just as well suited for the online detection of anesthesia levels (to prevent misdosages) as they are for the monitoring of astronauts (since these methods require very few wires).
Since its founding in the 18th century, L’ hôpital Necker pour enfants malades in Paris has been at the forefront of pediatric medicine in Europe and throughout the world. Dr. Christian Sainte-Rose who practices at Necker, signs off on a third of all the pediatric neurosurgeries in France. He has access to a wide database which he is making available to us. The goal is for NeuroVigil, Inc., to detect putative waves which the brain might produce well in advance of epileptic seizures in order to preempt them with anti-convulsants.
The Max Planck Institute for Psychiatry in Munich is responsible for all of the Sleep studies by the Max Planck society in Germany. It is the largest sleep center in Europe, and was the first center in the world to combine NMR and EEG recordings simultaneously, allowing for unprecedented spatial and temporal resolution of brain patterns in the same patients. Dr. Thomas Wetter is the head of the Neurophysiology of Sleep laboratory and Dr. Elizabeth Friess directs the Genetics of Human Sleep Group at MPI - Munich. They have already made control data from healthy subjects available to us. Dr. Friess would like us to analyze brain waves from identical twins in order to find out whether there is a genetic predisposition to the spectral structures of sleep rhythms.
Neurosynch, a California-based company, uses EEG to analyze patients suffering from autism. Using a technique called Sensorymotor-beta neurofeedback (SMR), developed by Neurosynch co-founder Dr. Barry Sterman, autistic patients try to control their brain patterns. Since epileptic seizures during sleep are common amongst autistic patients, Sandra Ackerman, president and co-founder of Neurosynch and Dr. David Kaiser, director of Technology Development, have asked NeuroVigil to analyze sleeping patterns of autistic patients before and after SMR treatment to assess whether or not there is a reduction in epileptic activity.
ResMed (ASX: RMD and NYSE: RMD) is a leading developer, manufacturer and marketer of products for the screening, treatment and long-term management of sleep-disordered breathing (SDB) and other respiratory disorders. ResMed operates in over 65 countries via 16 direct offices and a network of distributors with extensive knowledge and experience of local markets. Dr. Peter Farrell, Chairman and CEO of ResMed, would like NeuroVigil, Inc., to analyze brain patterns of apnea patients before and after treatment. Such a study might uncover a neural correlate of apnea which could be used to build portable CPAPS capable of restricting the delivery of positive airflow only during the apneic episodes.
Stanford University’s Center of Excellence for the Diagnosis and Treatment of Sleep Disorders is one of the premier sleep disorders investigation centers. The center encompasses the Sleep Disorders Clinics, the Center for Narcolepsy, the Center for Human Sleep Research, the School of Sleep Medicine, the Primary Care Sleep Education Project, Behavioral Sleep Medicine, Sleep Surgery and the Sleep and Circadian Neurobiology Laboratory. Dr. Emmanuel Mignot is the Director of the Center for Narcolepsy, which discovered the Narcolepsy gene. Dr. Jed Black is a clinician at the center treating a large number of patients. Drs. Mignot and Black have volunteered to contribute EEG data from patients with narcolepsy and other pathologies.
The UCSD Veterans Affairs Medical Center is a longtime collaborator of ours. Founded by the late Dr. J. Christian Gillin, a pioneer in sleep research, the Sleep Disorders Center, is at the very forefront clinical sleep research, encompassing an unusual mix of world class clinicians and sleep researchers. Dr. Sonia Ancoli-Israel directs the prestigious center and has provided us with sleep data from Alzheimer’s and narcolepsy patients in order for us to isolate neural correlates of these diseases which might be present in the sleep data. Dr. Sean Drummond continues to provide us with excellent control data and support from healthy subjects.
Dr. Mark Eric Dyken is Director of the Sleep Disorders Center at the University of Iowa. His studies on sleep disorders have resulted in his appointment to a number of national study groups and he is listed in “Best Doctors” in sleep medicine. Amongst his many contributions, his work defining the relationship between obstructive sleep apnea (OSA) and stroke and death is often referenced to justify the aggressive treatment of OSA. Dr. Dyken has a wide database of recordings from patients with apnea, narcolepsy and other disorders which he is making available to us.
Prof. Dr. med. Peter Lederer is a leading internist, gastroenterologist and diabetologist in private practice in Germany. Dr. Lederer would like us to check if there are particular EEG patterns associated with internal and gastric disorders, such as dyspepsia, irritable bowel syndrome, etc. Such patterns could be used as a diagnostic tool for internal disorders and their absence could be an indicator of recovery.
We have received numerous requests from other potential collaborators including:
Mr. Taj Hudson, Biopac Systems, Inc., (rats).
Dr. Leah Scott, DSTL - British Ministry of Defence (Marmosets, Rhesus Monkeys - Gulf War Syndrome).
Dr. Bruce Cohen, California Institute of Technology (mice – epilepsy).
California Institute of Technology (mice – brain circuitry, neuroengineering).
Dr. Ken Miller, Columbia University (computational modeling).
Mr. Nima Dehghani, Duke University, (human sleep – intracranial recordings).
Dr. Edward Boyden, Massachusetts Institute of Technology (mice – sleep)
Max Planck Institute for Psychiatry (humans – sleep patterns in patients with neuropathologies).
Dr. Niels Rattenborg, Max Planck Institute for Ornithology - Seewiesen (birds - sleep).
Novartis (humans - sleep and anesthesia).
Mr. Steve Ebright, Neurofeedback (humans).
Dr. Tim Mullen, Palo Alto Research Center, (humans).
Dr. Steven H. Woodward, Palo Alto VAMC (humans).
Dr. Todd Kirby, Respironics (humans – apnea).
Dr. Fred H. Gage, The Salk Institute for Biological Studies (mice – non-invasive sleep recordings, neuroplasticity).
The Salk Institute for Biological Studies (humans – sleep, data analysis).
Dr. Steve Sands, Stanford Research Institute (humans).
Dr. Antoine Adamantidis and Dr. Luis de Lecea, Stanford Research Institute (mice – sleep control)
Dr. Theresa Buckley, Stanford University (humans).
Dr. John Huguenard, Stanford University (rats, mice - epilepsy).
Cpt. Jed Hartings, United States Army –Walter Reed Army Medical Center (humans – intracranial recordings).
Dr. Carol Barnes, University of Arizona (monkeys – single cells and local field potentials).
Dr. Bruce McNaughton, University of Arizona (rats – single cells and local field potentials).
Matthew Baggott, University of California – Berkeley (humans).
Dr. Serapio Baca, University of California - Los Angeles (humans - breathing).
Dr. Rael Cahn, University of California – San Diego (humans – meditation and psychedelics).
Dr. Pamela Reinagel, University of California – San Diego (cats – anesthesia).
Dr. Michael Stryker, University of California – San Francisco (mice, cats, ferrets – anesthesia).
Dr. Victor Pulgar, University of Chile (sheep - ECogs).
University of Oxford (humans – sleep patterns in Schizophrenic patients).
Dr. med. Hans-Jürg Holdener, University of Zurich (human – neurosurgery –cancer –whiplash).
Harvard University’s Longwood campus has the densest concentration of hospitals in the world. At the Massachusetts General Hospital, in the department of Anesthesia and Critical Care, Dr. James Williams collects EEGs from rats and humans subjected to varying amounts and types of anesthetics. At the Brigham & Women’s Hospital, Dr. Charles Czeisler, the leader of NASA’s National Space Biomedical Research Institute’s Human Performance Factors, Sleep and Chronobiology Team analyzes brain patterns from sleeping astronauts in orbit. Dr. Czeisler presided over STS-95, the mission which brought John Glenn back to space. Drs. Williams and Czeisler think that the single channel capability of the methods developed by NeuroVigil, Inc., are just as well suited for the online detection of anesthesia levels (to prevent misdosages) as they are for the monitoring of astronauts (since these methods require very few wires).
Since its founding in the 18th century, L’ hôpital Necker pour enfants malades in Paris has been at the forefront of pediatric medicine in Europe and throughout the world. Dr. Christian Sainte-Rose who practices at Necker, signs off on a third of all the pediatric neurosurgeries in France. He has access to a wide database which he is making available to us. The goal is for NeuroVigil, Inc., to detect putative waves which the brain might produce well in advance of epileptic seizures in order to preempt them with anti-convulsants.
The Max Planck Institute for Psychiatry in Munich is responsible for all of the Sleep studies by the Max Planck society in Germany. It is the largest sleep center in Europe, and was the first center in the world to combine NMR and EEG recordings simultaneously, allowing for unprecedented spatial and temporal resolution of brain patterns in the same patients. Dr. Thomas Wetter is the head of the Neurophysiology of Sleep laboratory and Dr. Elizabeth Friess directs the Genetics of Human Sleep Group at MPI - Munich. They have already made control data from healthy subjects available to us. Dr. Friess would like us to analyze brain waves from identical twins in order to find out whether there is a genetic predisposition to the spectral structures of sleep rhythms.
Neurosynch, a California-based company, uses EEG to analyze patients suffering from autism. Using a technique called Sensorymotor-beta neurofeedback (SMR), developed by Neurosynch co-founder Dr. Barry Sterman, autistic patients try to control their brain patterns. Since epileptic seizures during sleep are common amongst autistic patients, Sandra Ackerman, president and co-founder of Neurosynch and Dr. David Kaiser, director of Technology Development, have asked NeuroVigil to analyze sleeping patterns of autistic patients before and after SMR treatment to assess whether or not there is a reduction in epileptic activity.
ResMed (ASX: RMD and NYSE: RMD) is a leading developer, manufacturer and marketer of products for the screening, treatment and long-term management of sleep-disordered breathing (SDB) and other respiratory disorders. ResMed operates in over 65 countries via 16 direct offices and a network of distributors with extensive knowledge and experience of local markets. Dr. Peter Farrell, Chairman and CEO of ResMed, would like NeuroVigil, Inc., to analyze brain patterns of apnea patients before and after treatment. Such a study might uncover a neural correlate of apnea which could be used to build portable CPAPS capable of restricting the delivery of positive airflow only during the apneic episodes.
Stanford University’s Center of Excellence for the Diagnosis and Treatment of Sleep Disorders is one of the premier sleep disorders investigation centers. The center encompasses the Sleep Disorders Clinics, the Center for Narcolepsy, the Center for Human Sleep Research, the School of Sleep Medicine, the Primary Care Sleep Education Project, Behavioral Sleep Medicine, Sleep Surgery and the Sleep and Circadian Neurobiology Laboratory. Dr. Emmanuel Mignot is the Director of the Center for Narcolepsy, which discovered the Narcolepsy gene. Dr. Jed Black is a clinician at the center treating a large number of patients. Drs. Mignot and Black have volunteered to contribute EEG data from patients with narcolepsy and other pathologies.
The UCSD Veterans Affairs Medical Center is a longtime collaborator of ours. Founded by the late Dr. J. Christian Gillin, a pioneer in sleep research, the Sleep Disorders Center, is at the very forefront clinical sleep research, encompassing an unusual mix of world class clinicians and sleep researchers. Dr. Sonia Ancoli-Israel directs the prestigious center and has provided us with sleep data from Alzheimer’s and narcolepsy patients in order for us to isolate neural correlates of these diseases which might be present in the sleep data. Dr. Sean Drummond continues to provide us with excellent control data and support from healthy subjects.
Dr. Mark Eric Dyken is Director of the Sleep Disorders Center at the University of Iowa. His studies on sleep disorders have resulted in his appointment to a number of national study groups and he is listed in “Best Doctors” in sleep medicine. Amongst his many contributions, his work defining the relationship between obstructive sleep apnea (OSA) and stroke and death is often referenced to justify the aggressive treatment of OSA. Dr. Dyken has a wide database of recordings from patients with apnea, narcolepsy and other disorders which he is making available to us.
Prof. Dr. med. Peter Lederer is a leading internist, gastroenterologist and diabetologist in private practice in Germany. Dr. Lederer would like us to check if there are particular EEG patterns associated with internal and gastric disorders, such as dyspepsia, irritable bowel syndrome, etc. Such patterns could be used as a diagnostic tool for internal disorders and their absence could be an indicator of recovery.
We have received numerous requests from other potential collaborators including:
Mr. Taj Hudson, Biopac Systems, Inc., (rats).
Dr. Leah Scott, DSTL - British Ministry of Defence (Marmosets, Rhesus Monkeys - Gulf War Syndrome).
Dr. Bruce Cohen, California Institute of Technology (mice – epilepsy).
California Institute of Technology (mice – brain circuitry, neuroengineering).
Dr. Ken Miller, Columbia University (computational modeling).
Mr. Nima Dehghani, Duke University, (human sleep – intracranial recordings).
Dr. Edward Boyden, Massachusetts Institute of Technology (mice – sleep)
Max Planck Institute for Psychiatry (humans – sleep patterns in patients with neuropathologies).
Dr. Niels Rattenborg, Max Planck Institute for Ornithology - Seewiesen (birds - sleep).
Novartis (humans - sleep and anesthesia).
Mr. Steve Ebright, Neurofeedback (humans).
Dr. Tim Mullen, Palo Alto Research Center, (humans).
Dr. Steven H. Woodward, Palo Alto VAMC (humans).
Dr. Todd Kirby, Respironics (humans – apnea).
Dr. Fred H. Gage, The Salk Institute for Biological Studies (mice – non-invasive sleep recordings, neuroplasticity).
The Salk Institute for Biological Studies (humans – sleep, data analysis).
Dr. Steve Sands, Stanford Research Institute (humans).
Dr. Antoine Adamantidis and Dr. Luis de Lecea, Stanford Research Institute (mice – sleep control)
Dr. Theresa Buckley, Stanford University (humans).
Dr. John Huguenard, Stanford University (rats, mice - epilepsy).
Cpt. Jed Hartings, United States Army –Walter Reed Army Medical Center (humans – intracranial recordings).
Dr. Carol Barnes, University of Arizona (monkeys – single cells and local field potentials).
Dr. Bruce McNaughton, University of Arizona (rats – single cells and local field potentials).
Matthew Baggott, University of California – Berkeley (humans).
Dr. Serapio Baca, University of California - Los Angeles (humans - breathing).
Dr. Rael Cahn, University of California – San Diego (humans – meditation and psychedelics).
Dr. Pamela Reinagel, University of California – San Diego (cats – anesthesia).
Dr. Michael Stryker, University of California – San Francisco (mice, cats, ferrets – anesthesia).
Dr. Victor Pulgar, University of Chile (sheep - ECogs).
University of Oxford (humans – sleep patterns in Schizophrenic patients).
Dr. med. Hans-Jürg Holdener, University of Zurich (human – neurosurgery –cancer –whiplash).